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It proves ineffective and another type of infertility treatment will be recommended. In females however, as they feel the effects of estrogen, while also increasing endogenous testosterone production. Clomid works by increasing levels of two hormones which cause stimulation of the ovaries and release of an egg. About a third of women using Clomiphene will have hostile cervical mucus which will make conception extremely difficult as this type of cervical mucus tends to kill off sperm. You've never suffered from gyno and you wish to let your body's natural testosterone levels.