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Medications with a known history of reacting with Levaquin include cisapride, depridil, droperidol, methadone, pentamidine, theophylline, blood thinners like warfarin or Coumadin, oral diabetes medication, insulin, and aspirin. Diarrhea that usually ends after treatment is a common problem caused by antibiotics. Levofloxacin is rapidly and essentially completely absorbed after oral administration. Levofloxacin is a synthetic broad spectrum antibacterial agent for oral and intravenous administration.