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Prednisolone prevents the release of substances in the body. Prednisone may interact with estrogens and phenytoin. Prednisolone is a corticosteroid used to treat various inflammatory and allergy conditions as well as other diseases. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Deltasone is used in much higher doses than the levels of corticosteroids produced naturally by the body.