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Prednisolone is a corticosteroid medicine. Prednisone has very little mineral corticoid activity, so it is not used in the management of inflammatory conditions or diseases in which the immune system plays an important role. Prednisolone is a corticosteroid medicine. It works by modifying the body's immune response to various conditions and decreasing inflammation. You have surgery or a medical emergency. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control.