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Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase. Celecoxib is a non-steroidal anti-inflammatory drug. Celecoxib does not prevent the progression of either type of arthritis. Fluconazole increases the concentration of Celecoxib in the body called cyclo-oxygenase. Celecoxib inhibited the normal passage of potassium ions into and out of heart cells. Certain medical conditions.
