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Nexium capsules should be taken at least one hour before a meal. What should you watch for while taking Esomeprazole? Esomeprazole reduce the production of acid in the stomach. Esomeprazole capsules should be taken at least one hour before a meal. Nexium is used to treat the infection that causes ulcers occurring just beyond the exit from the stomach. Nexium is available in a powdered intravenous formulation to be reconstituted for injection. In the wall of the stomach that produces acid.