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Metformin is used as a first line treatment of type 2 diabetes. Glucophage tablets contain the active ingredient Metformin hydrochloride. Most benefit from it. Glucophage should be taken with meals. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose you absorb from your food and the amount of glucose made by your liver.