Wellbutrin sustained-release is an antidepressant medication that is used primarily to treat depression. Taking the correct Wellbutrin dosage to treat your depression is a determination that is best left to your medical professional team. There is at least eight hours in between doses. There are a number of different treatment options for depression and generic Wellbutrin. Bupropion is easy to take and the side effects from taking it are minimal. Antidepressants can help prevent suicidal thoughts and provide other important health benefits.