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Once-daily Valtrex is also the only medication proven to reduce the amount of time for an outbreak if taken soon enough. Once-daily Valtrex is also the only medication proven to reduce the amount of time for an outbreak if taken soon enough. How is daily therapy different from taking Valtrex to treat each outbreak? Valtrex is most effective if it is started within 48 hours of when the rash first appears. There are no studies that show how well Valaciclovir will work if you take it more than 24 hours after the start of signs or symptoms.
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