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A dose adjustment or special tests to safely take Prednisolone. Prednisone may interact with estrogens and phenytoin. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical.

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"Do not stop using Prednisolone suddenly, or you could have unpleasant withdrawal symptoms. As corticosteroids reduce the normal response of the immune system and prevent the body from rejecting transplanted organs. Before the needed effect is achieved."

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