Generic Wellbutrin is required to achieve steady blood levels of the drug in your blood. If you have trouble sleeping, you may be taking your dose too close to bedtime. Length of Bupropion therapy is seven to twelve weeks. It, since this helps minimize side effects. The medication. Bupropion hydrochloride is an anxiolytic drug that works by inhibiting neuronal uptake of norepinephrine and dopamine reuptake inhibitor. Often a very effective and relatively fast-acting antidepressant, Bupropion can be used recreationally.