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Bupropion is easy to take and the side effects from taking it are minimal. Bupropion approximately doubles the likelihood of successfully quitting smoking compared to using no quit medication. Wellbutrin sustained-release is an antidepressant medication that is used primarily to treat depression. Generic Wellbutrin is usually taken one to three times a day and may be taken with or without food. Bupropion is one of two prescription medications which can help balance chemicals in your brain to reduce your withdrawal symptoms.