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Based on a patient's reaction to the drug, your dose of Baclofen may be increased gradually to 80 mg per day over several doses. Whenever you take medication, be sure to take all of the prescribed doses. Baclofen tends to cause giddiness, make sure you avoid taking part in any activities that require you to be alert and concentrated. Many drugs can increase the effects of Lioresal, which can lead to heavy sedation.

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