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Azithromycin may enhance the anti-blood-clotting effects of warfarin and possibly other anticoagulant medicines. Broad-spectrum antibiotics as Zithromax can sometimes cause inflammation of the bowel. Zithromax is an unusual antibiotic in that it stays in the body for quite a long time as it has a prolonged half-life that allows for once a day dosing and also for short-term treatment courses for most infections. Clinical trials have shown that Azithromycin ought to be taken at least one hour pending to or two hours following meals.