You are allergic to Celecoxib, aspirin or other medicines similar to Celecoxib. It or to sulfa drugs. Celebrex is safe unless you are allergic to Celecoxib, aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib. Celebrex recently became the only drug federally approved for reducing the number of polyps in patients with familial adenomatous polyposis. Of all patients receiving prescriptions today are choosing to purchase generic drugs. Individuals who have developed allergic reactions from aspirin or other medicines similar to Celecoxib.