You might find it convenient to take Paxil and talk to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight. You stop taking Paxil suddenly. It convenient to take Paxil with breakfast. You stop taking Paxil suddenly. Presently, serotonin-enhancing drugs are the therapeutic regimens for those who are suspect of having a depressed state or mood disorder. Paroxetine is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors approved by the FDA as a safe and effective for long-term use and is well tolerated.