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Prednisone and Prednisolone are members of the glucocorticoid class of hormones. As replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. It may still pose a risk to the infant. Prednisone may interact with estrogens and phenytoin. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Corticosteroids reduce the normal response of the immune system and prevent the body from rejecting transplanted organs.