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Prednisolone is a corticosteroid medicine. Prednisolone is a corticosteroid medicine. Prednisone is the most commonly-prescribed oral corticosteroid. Prednisone may interact with estrogens and phenytoin. You could have unpleasant withdrawal symptoms. In the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Prednisone and Prednisolone are members of the glucocorticoid class of hormones.